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Effects of the combination of Hyperbaric Oxygen and 5-Fluorouracil on proliferation and metastasis of human nasopharyngeal carcinoma CNE-2Z cells
ABSTRACT
Objective: We investigated the effects of hyperbaric oxygen (HBO2) and /or 5- Fluorouracil (5-FU) on the profilation and metastasis of human nasopharyngeal carcinoma (NPC) cell line CNE-2Z and the underlying mechanisms involved.
Conclusions:
Simple HBO2 treatment after 48 and 72 hours could inhibit the proliferation of nasopharyngeal carcinoma CNE-2Z cells. The combination of HBO2 with 5-FU exhibited significant synergismn in the suppresion of NE2Z cell proliferation only after 48 hours of treatment compared to 5-FU. Simple HBO2 treatment could not reduce the high expressions of NMP-9 and VEGF and inhibit the metastasis of human NPC CNE2Z cells, no synergistic effect was observed for the combination of HBO2 with 5-FU compared to 5-FU alone.
Hbo2 treatment alone after 48 and 72 hours significantly inhibit the proliferation of human nasopharyngeal carcinoma cells, but the combination of HBO2 and 5-FU significantly inhibited only the proliferation of human nasopharyngeal carcinoma cells after 48 hours. HBO2 treatment alone could not significantly reduce the high expressions of NMP-9 and VEGF in the nasopharyngeal carcinoma cells and could not inhibit the invasion and migration of nasopharyngeal carcinoma cells, either. The same effects were observed for the combination of HBO2 with 5-FU |
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